P111 Developmental pharmacogenetics of CYP2D6 in Chinese children: loratadine as a probe drug

Effect of cyp2d6*10 allele on the pharmacokinetics of loratadine in chinese subjects.

Loratadine is known to be a substrate for both CYP3A4 and CYP2D6 based on a previous in vitro study. In view of the large interindividual variability in loratadine pharmacokinetics and the greater genetically determined variability of CYP2D6 activity than of CYP3A4 in vivo, we hypothesized that CYP2D6 polymorphisms may contribute to the pharmacokinetic variability of loratadine. The purpose of ...

Pinoline may be used as a probe for CYP2D6 activity.

Pinoline, 6-methoxy-1,2,3,4-tetrahydro-beta-carboline, is a serotonin analog that selectively inhibits the activity of monoamine oxidase-A and shows antidepressant activity. Our previous study using a panel of recombinant cytochrome P450 (P450) enzymes suggests that pinoline O-demethylation may be selectively catalyzed by polymorphic CYP2D6. The current study, therefore, aimed to delineate the ...

Pinoline May Be Utilized as a Probe for CYP2D6 Activity

Pharmacogenetics and breast cancer endocrine therapy: CYP2D6 as a predictive factor for tamoxifen metabolism and drug response?

The identification of genetic polymorphisms that influence the efficacy and safety of therapies for breast cancer may allow future treatments to be individualised based not only on tumour characteristics but also on host genetics. Genetic factors that affect the metabolism, efficacy and safety of tamoxifen, one of the most common drugs used for the treatment and prevention of breast cancer, hav...

The Persian developmental sentence scoring as a clinical measure of morphosyntax in children

Background: Developmental Sentence Scoring (DSS) was developed as a numerical measurement and a clinical method based on the morphosyntactic acquisition in the English language. The aim of this study was to develop a new numerical tool similar to DSS to assess the morphosyntactic abilities in Persian-speaking children.   Methods:  In this cross-sectional and comparative study, the ...